Product Pipeline

NeuRepair™ – A Novel Non-Opiod Therapy for Neuropathic Pain

Painful lumbar radiculopathy (PLR) and painful diabetic neuropathy (PDN) affect approximately 40 million patients in EU and US. Currently there is no registered drug for PLR and around  50% of patients with PDN are inadequately treated.

The pain associated with PLR and PDN originates from diseased sensory neurons that mediate sensations including pressure and heat from arms and legs to the spinal cord and brain. In PLR, a physical compression of the sensory nerves entering the spinal cord causes a pain known as sciatica, while the sensory neuropathy and pain in PDN are caused by metabolic injury. For both PLR and PDN there is a great medical need for tolerable therapies like NeuRepair that can protect, restore, and regenerate sensory neurons and thereby ameliorate the pain.

EarRepair™ – A Novel Reparative Gene Therapy Device for Treatment of Sensorineural Hearing Loss

More than 35 million patients suffer from sensorineural hearing loss (SNHL), a condition frequently impacting people’s ability to socialize, work and to live normal lives. SNHL develops in response to damage of the sensory hair cells and nerve pathways of the inner ear that sense and transmit sound  to the brain. Building on the direct implantation in the cochlea, we have developed a gene therapy device that complements and expands the therapeutic scope for many patients currently with suboptimal treatment options. Encouraged by the therapeutic effects obtained in preclinical models EarRepair has entered preclinical safety studies to prepare for clinical translation.

EpiRepair™ – A first in class reparative therapy for pharmacoresistant temporal lobe epilepsy (TLE)

Epilepsy affects tens of millions of individuals worldwide and is characterized by debilitating seizures, cognitive decline, and psychiatric disorders.  A significant portion of epilepsies in adults originate focally from temporal lobe structures. These TLEs cannot be cured and one third of all patients do not respond to pharmacological treatment. Even when effective at reducing seizures, the currently available drugs typically cause significant unwanted side effects.  Because of the focal nature of TLE, EC devices can target the anatomical structures and secrete potent antiepileptic biologics. Sinfonia’s EC-GDNF devices have shown strong antiepileptic effects in animal models of TLE and are associated with cognitive improvements and no evidence of side effects. 

Precision therapies in research phase

Frontotemporal dementia (FTD) and Parkinson’s disease (PD) are heterogeneous neurodegenerative disorders in terms of clinical expression and disease pathology. It is therefore unlikely that there will be a one-therapy-fix all solution. Rather, tailored therapies for specific disease subtypes are more likely to succeed.

Product

Indication

Research           Preclin. dev.

Phase I           Phase II

Sciatia

Painful diabetic neuropathy

Phase IIb

Phase IIa

FTDRepair

Injectable pipeline

GRN related frontotemporal dementia (FTD/GRN)

Preclinical (Proof of concept)

EarRepair

EpiRepair

PDRepair

Gene therapy pipeline

Sensorineural hearing loss

Pharmacoresistent Temporal lobe epilepsy

GBA1 related Parkinsons Disease (PD/GBA1)

GLP-tox

GLP-tox

Preclinical (Proof of concept)